Re: [討論] 有關NNT(Number needed to test)的疑問
※ 引述《anovachen (囧)》之銘言:
: ※ 引述《telepathy (RainbowDog)》之銘言:
: : Prevalence: 4.35%
: : Case(+)/total: 6/18 (33.3%)
: : Control(+)/total: 4/144 (2.8%)
: : Odds ratio: 17.5
: : P value: 2.2x10^-3
: : Sensitivity: 33.0
: : Specificity: 97.2
: : PPV: 34.9 % (以Prevalence, sensitivity, specificity校正)
: : NPV: 96.7 % (同上)
: : NNT: 91 ???
: → bmka:你算NNT的目的是什麼? 07/30 04:08
: → bmka:3.3怎麼看怎麼不對 07/30 04:09
: 推 anovachen:是答案不對,還是這答案沒有意義? 因為ARR是介入前 07/30 11:46
: → anovachen:發生率-介入後發生率。這邊似乎資訊不足以計算ARR? 07/30 11:47
: D D'
: E 6 12 (33.3%)
: E' 4 140 (2.8%)
: OR=(6*140)/(4*12)=17.5
: 問題是,暴露與非暴露代表的是治療的介入與否嗎?
: 如果暴露=介入,這樣很奇怪,反而介入組發病的比率(33.3%)更高。
: 到底這題能不能算NNT阿?
: 不知原PO能不能提供原始論文的連結?
當然可以!!!
HLA genotype and carbamazepine-induced cutaneous Adverse Drug Reactions:
A systematic review
http://www.ncbi.nlm.nih.gov/pubmed/23132554
我想知道~ Table2的表格 NNT怎麼算的??
上面原文是作者表格中第一個分析
下面是第二個例子
Prevalence: 2.9%
Population frequency: 7.1-12%
Case(+)/total: 45/77 (58.4%)
Control(+)/total: 54/420 (12.9%)
Odds ratio: 9.5
P value: 1.1x10^-16
Sensitivity: 58.4
Specificity: 87.1
PPV: 11.9 % (以Prevalence, sensitivity, specificity校正)
NPV: 98.6 % (同上)
NNT: 67 ???
由於Paper表格中列出三個例子, 都是我用簡單定義"NNT=1/ARR"算不出來的
(應該可以排出Paper自己算錯的可能?!)
我自已的例子是
Prevalence: 0.05%
Case(+)/total: 7/10 (70%)
Control(+)/total: 10/257 (3.9%)
Odds ratio: 57.6
P value: 1.19x10^-7
Sensitivity: 70
Specificity: 96.1
PPV: 0.89 % (以Prevalence, sensitivity, specificity校正)
NPV: 99.98 % (同上)
NNT: ???
我不知道NNT是不是有其他公式或是定義
或是還需要考慮什麼, 該怎麼修正才好
非常感謝各位的回覆 :)
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