Re: [問卦] 台灣用大劑量維C治療新冠重症的進度？

看板Gossiping作者yule1224 (政治是高明的騙術)時間2年前 (2021/05/22 04:24)推噓7(8推 1噓 10→)

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目前國際間用大劑量維他命C靜脈注射的治療研究報導可以參考這連結 https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-02851-4 希望台灣能趕緊加入這方面的研究這或許需要政府的主導帶領原文是英文我用goolge翻譯翻成中文，附在每段原文後，給大家方便參考對照... 標題: A new clinical trial to test high-dose vitamin C in patients with COVID-19 一項新的臨床試驗，用於在COVID-19患者中測試大劑量維生素C 作者: Anitra C. Carr With the 2019 novel coronavirus (2019-nCoV) outbreak now spreading across the world, people are seeking ways in which to potentially protect themselves from the virus or to alleviate its effects once caught. One such means that is being touted online and in the media is vitamin C. 隨著2019年新穎的冠狀病毒（2019-nCoV）爆發在全球範圍內蔓延，人們正在尋找潛在的方法來保護自己免受病毒感染或減輕其感染後的影響。維生素C是一種在網上和媒體上吹捧的手段 Vitamin C is best known for its antioxidant properties, being able to scavenge damaging reactive oxygen species, thus protecting the body’s cells and tissues from oxidative damage and dysfunction. However, the vitamin also has numerous other important functions within the body, many of which are known to support healthy immune function. During infection, vitamin C levels can become depleted and a person’s requirement for vitamin C increases with the severity of the infection [1]. In severe cases, this may require intravenous administration of gram doses in order to achieve high enough levels in the body to compensate for the enhanced turnover of the vitamin. 維生素C以其抗氧化特性而聞名，能夠清除有害的活性氧，從而保護人體的細胞和組織免受氧化損傷和功能障礙。但是，維生素在體內還具有許多其他重要功能，其中許多功能都可以支持健康的免疫功能。在感染過程中，維生素C含量可能會耗盡，並且隨著感染程度的增加，人們對維生素C的需求也會增加[1]。在嚴重的情況下，這可能需要靜脈內注射克劑量的藥物，以達到體內足夠高的水平，以補償增加的維生素周轉率。 As of February 2020, the clinical characteristics of patients hospitalized with COVID-19-related pneumonia indicated that 26% were transferred to the ICU because of complications such as ARDS and shock [2]. A recently published RCT carried out in the USA in 167 patients with sepsis-related ARDS indicated that administration of ~ 15 g/day of IV vitamin C for 4 days may decrease mortality in these patients [3]. An earlier IV vitamin C trial of patients admitted to the ICU with pneumonia included hydrocortisone administration [4], however, systemic corticosteroid treatment has not been shown to have significant benefits in patients with COVID-19 [5]. 截至2020年2月，因CODID-19相關性肺炎住院的患者的臨床特徵表明，有26％的患者由於ARDS和休克等並發症而被轉移至ICU [2]。最近在美國對167例敗血症相關性ARDS患者進行的RCT研究表明，每天約15克/天的靜脈注射維生素C ，4 天可以降低這些患者的死亡率[3]。較早的時候，是對接受ICU肺炎治療的患者進行的IV維生素C試驗包括氫化可的松給藥[4]，然而此方法，尚未顯示全身性皮質類固醇治療對COVID-19患者俱有明顯的益處[5]。 Just recently registered on clincialtrials.gov (Identifier: NCT04264533), a new clinical trial to investigate vitamin C infusion for the treatment of severe 2019-nCoV infected pneumonia has begun in Wuhan, China. This is one of the first RCTs to test the effects of IV vitamin C in patients infected with this virus. In this trial, the investigators will treat 140 patients with a placebo control or intravenous vitamin C at a dose of 24?g/day for 7?days. They will assess requirements for mechanical ventilation and vasopressor drugs, organ failure scores, ICU length of stay and 28-day mortality. 最近在clincialtrials.gov上註冊（標識號：NCT04264533），一項新的臨床試驗旨在研究維生素C輸注治療嚴重的2019-nCoV感染性肺炎的治療方法，已在中國武漢開始。這是首批測試靜脈注射型維生素C對感染此病毒的患者的影響的 RCT之一。在該試驗中，研究人員將以24克/天的劑量治療140例安慰劑對照靜脈注射維生素C的患者，持續7天。他們將評估機械通氣和血管升壓藥的需求，器官衰竭評分，ICU住院時間和28天死亡率。 The investigators of the new study hope to complete the trial by the end of September. Although the findings of this trial will be too late for the many thousands of people currently infected with the virus, the study will nevertheless provide valuable information as to the potential mitigation of symptoms by vitamin C during future viral outbreaks. 這項新研究的研究人員希望在9月底前完成試驗。儘管該試驗的結果對於目前感染該病毒的成千上萬的人來說為時已晚，但該研究仍將提供有價值的信息，說明在未來病毒暴發期間維生素C可能緩解症狀。 Availability of data and materials N/A References 1. Carr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care. 2017;21:300. 2. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. 3. Fowler AA 3rd, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR 2nd, Natarajan R, Brophy DF, Sculthorpe R, Nanchal R, Syed A, Sturgill J, Martin GS, Sevransky J, Kashiouris M, Hamman S, Egan KF, Hastings A, Spencer W, Tench S, Mehkri O, Bindas J, Duggal A, Graf J, Zellner S, Yanny L, McPolin C, Hollrith T, Kramer D, Ojielo C, Damm T, Cassity E, Wieliczko A, Halquist M. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 2019;322(13):1261–70. 4. Kim WY, Jo EJ, Eom JS, Mok J, Kim MH, Kim KU, Park HK, Lee MK, Lee K. Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: propensity score-based analysis of a before-after cohort study. J Crit Care. 2018;47:211–8. 5. Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, Xiao W, Wang YN, Zhong MH, Li CH, Li GC, Liu HG. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J. 2020. https://doi.org/10.1097/CM9.0000000000000744. -- 政治是高明的騙術，你又被騙了嗎別輕易相信輿論風向，別輕易無疑慮的信那些餵給你的資料別那麼容易被簡短的口號給洗腦 -- ※ 發信站: 批踢踢實業坊(ptt.cc), 來自: 135.0.168.174 (加拿大) ※ 文章網址: https://www.ptt.cc/bbs/Gossiping/M.1621628696.A.2B5.html

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05/22 04:28, 2年前 , 1^F

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05/22 04:29, 2年前 , 2^F

05/22 04:29, 2^F

這是對確診病患的治療，相關研究 ※ 編輯: yule1224 (135.0.168.174 加拿大), 05/22/2021 04:32:04

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05/22 04:30, 2年前 , 3^F