Re: 邱教授作業智囊團請注意!!
5.
A.
a.The Sda is expressed on glycolipid and glycoprotein
in human gastrointestinal mucosa.
Int J Cancer. 1996 Sep 4;67(5):626-31
b.More than 90% of individuals of Caucasian origin
express the carbohydrate antigen Sda on their
erythrocytes and in a few other tissues,
including colon and kidney
J. Biochem. 134, 675-682 (2003)
C. Sda activity has also been detected abundantly in
stomach, kidney, and colon tissue.
Carbohydr Res. 299(3):181-95.
B
The expression of _4GalNAc-T in colon shows a clear
relationship with tissue differentiation.
在正常的cell或是組織中沒有發現sda會因為不同的
developmental stage而有所不同 ,
but in the colon cancer cell line Caco2,
which shows a more differentiated phenotype and
which can further differentiate in vitro,
lowβ4GalNAc-T activity that increases upon
differentiation can be detected.
Biochem. Biophys. Res. Commun. 180, 681-686
J. Biochem. 134, 675-682 (2003)
C.
The expression of the Sda determinant dramatically
decreases in cancer tissue (colon).
becauseβ4GalNAc-T activity decreases in human colon
carcinoma
Int J Cancer. 1996 Sep 4;67(5):626-31
D.
Yes(paper是1970的，所以找不到)
Race. R. R.,and Sanger, R. The Sid groups.
In: Blood Group in Man, Ed.6,pp.395-405.Qxford,
United Kingdom: Blackwell Publication, 1975.
6.
In transgenic mice where β4GalNAc-T is overexpressed
in extrasynaptic regions in skeletal myofibers,
the development of the neuromuscular synapse is
profoundly altered, suggesting that the Sda antigen
is involved in controlling the expression of synaptic
molecules
Dev. Biol. 242, 58-73
β4GalNAc-T may act as a metastasis-suppression
gene in colon cancer and, possibly, in other malignancies.
J. Biochem. 134, 675-682 (2003)
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