Re: [問題] ISA-β blocker不能用在angina的原因？？
※ 引述《premire (熱騰騰的泡麵)》之銘言：
: 關於這個問題一直存在 後來翻了Pharmacotherapy Handbook 第六版
: 後發現內文以下（翻中）：
: "ISA會將HR的reduction minimized, 因此limiting a reduction in MVO2"
: 有人可以跟我解釋這段的意思嗎？感覺α的活性和HR無關呀..
我參考完整版的p.280：
....intrinsic sympathomimetic activity appears to be detrimental in rest
or severe angina because the reduction in heart rate would be minimized,....
by eMedicine
Intrinsic sympathomimetic activity:
Some beta-blockers, such as pindolol and acebutolol, also have beta-agonist
properties. While their agonist property is weaker than that of
catecholamines, they are capable of stimulating beta-receptors, especially
when catecholamine levels are low. These agents are said to have intrinsic
sympathomimetic activity; this agonist property is protective in overdoses
所謂的ISA (intrinsic sympathomimetic activity)是指partial beta-agonist
所以會增加HR，應該不是跟alpha有關
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