Re: 免疫整理6
其實我會那樣猜是因為我覺得所謂傳遞訊號不要再做recombination
應該就是inactivate RAG-1 and 2
不然是??
Allelic exclusion seems to operate without substantial allelic preference,
as the alleles at each locus are generally expressed at roughly equal
frequencies; chance probably determines which allele rearranges first. In
light-chain isotypic exclusion, however, there is a decided preference for
which locus is rearranged first, and the ratios of κ-expressing versus λ-
expressing mature B cells vary from one extreme to the other in different
species. In mice and rats it is 95% κ to 5% λ; in humans it is typically
65:35, and in cats it is 5:95, the opposite of that in mice. These ratios
correlate most strongly with the number of functional Vk and Vλ gene
segments in the species genome. They also reflect the kinetics and
efficiency of gene segment rearrangements. The κ:λ ratio in the mature
lymphocyte population is useful in clinical diagnostics, as an aberrant κ:λ
ratio indicates the dominance of one clone and the presence of a
lymphoproliferative disorder, which may be malignant.
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