Re: 可不可以幫我解答

看板NTUIBMB93作者Lipaty (月餅不要吃太多)時間19年前 (2004/10/08 01:42)推噓8(9推 1噓 3→)

留言13則, 4人參與討論串5/5 (看更多)

※ 引述《YuChHa (偷心計畫)》之銘言： : ※ 引述《cave (三毛貓：水深火熱)》之銘言： : : in vivo 情況下， : : mitochondria 藉由 "proton-motive force" 驅動 ATP synthase。 : : 因為 intermembrane space(外) proton conc. 高，matrix(內) : : proton conc.低，外部的 proton 會經 ATP synthase 進入內部， : : 此時利用 proton concentration gradient 儲存的化學位能， : : 驅使 ATP synthase 合成 ATP。 : : 所以在 in vitro 情況下也相同，當外部 pH 低 (proton 濃度高)， : : 可以促使 mitochondria membrane 上的 ATP synthase 產生 ATP。 : : 這題從結果現象反推： : : 在肌肉劇烈運動或 mitochondria function 受損時，cell 會進行 : : lactic acid fermentation。由此推測，這個新藥可能造成 : : mitochondria DNA 的損壞，於是 electron-carrier complexes 失 : : 去正常功能，electron transport chain 無法正常進行，最後細胞 : : 不能 uptake oxygen，細胞在缺氧狀態下，只好進行 lactic acid : : fermentation。 : : "drastic overproduction of lactic acid and liver failure"就 : : 這樣產生了。 : : (ps 不曉得有沒有說錯的地方以上是不負責任版 :p) : 網路上看到的!! : The key concept is that lactic acid is produced only when there is exertion : for the muscles or when mitochondrial function is inhibited. : The drastic overproduction of lactic acid and liver failure due to a drug : that acts like a nucleotide would only occur if this analogue was : incorporated into mitochondrial DNA, disrupting mitochondria function. : Tragically, that is exactly what happened in this case. : The overproduction of lactic acid is evidence that : fermentation is occuring on a large scale. : Knowing that the drug can interfere with DNA replication, : it makes sense to conclude that it has interefered with mitochondrial : DNA and affected normal ATP production. : If the mitochondria's ability to produce ATP were disrupted, : the ATP would have to be produced outside the mitochondria, : by fermentation taking place in the cytosol. : Though it is normal for the body to use fermentation, : especially by muscle cells during hard excercise, : fermentation is a temporary response that cannot be sustained in humans. : In the case of patients in this clinical trial, : ongoing exposure to the drug would disrupt mitochondrial DNA as use continued, : rendering more mitochondria unable to produce ATP. : Lactic acid production as a by-product of fermentation would continue, : and eventually overwhelm the liver. ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ 位什麼不會是全身性的? -- ※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 140.112.121.97

推

potty

140.112.129.8 10/08, , 1^F

140.112.129.8 10/08, 1^F

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Lipaty

61.223.31.40 10/08, , 2^F

61.223.31.40 10/08, 2^F

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cave

218.161.15.123 10/08, , 3^F

218.161.15.123 10/08, 3^F