演講公告
清華大學、交通大學
統 計 學 研 究 所
專 題 演 講
題 目: The Effects of Population Stratification and Misclassification in
Studies of Gene-Environment Interactions
主講人: 鄭光甫教授 (中國醫藥大學生物統計中心)
時 間: 96年10月12日（星期五）10：40 - 11：30
（上午10：20-10：40茶會於統計所821室舉行）
地 點: 清大綜合三館837室
Abstract
Population stratification (confounding by ethnicity) and misclassification of
genotype may cause the usual tests in case-control studies producing spurious
gene-disease associations. To control for the resulting bias, several
powerful approaches have been proposed using unlinked markers. However, the
effects of population stratification and misclassification of genotype and
environmental exposure in studies of gene-environment interactions are still
not clear. In this paper, we quantify the effects of population
stratification and misclassification in case-control and case-only studies
under general conditions. We also present two conditions under which the
effect of population stratification and/or misclassification does not exist
in case-control or case-only studies of gene-environment interactions. The
two conditions are: (1) genotype and environmental exposure are conditionally
independent given stratification variable, and (2) environmental exposure and
stratification variable are conditionally independent given genotype. We
conducted a simulation study, using parameter values from real examples, to
compare the performance of different tests for gene-environment interactions.
Our results show that under the given simulation conditions, case-only
approach for studying gene-environment interactions is the most powerful
method, which is not only insensitive to population stratification and
misclassification but also has the best performance in power.
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