Re: [問題] Ras MAPK pathway
※ 引述《bb89233 (life)》之銘言：
: In the Ras/MAPK pathway
: (A) SOS causes the GDP on Ras to be replaced by GTP
: (B) the activation of the EGF receptor triggers SOS to bind the receptor
: (C) MAP kinases are activated by Ser/Thr phosphorylation
: (D) activation of ERK1 results in phosphorylation of cytoplasmic transcription
: factors. causing them to relocate to the nucleus
: (E) answer A and B
: 請高手幫解...謝謝
Ans: E
For C:
ERKs and other MAPKs require both Thr and Tyr phosphorylation for full
activity. (at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human
ERK2.)
NOT Ser/Thr.
For D:
In the nucleus, active ERK phosphorylates transcription factors and so
nuclear translocation of ERK is critical for gene expression.
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