Re: [問題] Neuronal inoic currents好難
該篇文章中的字彙解釋
A-type K+ current
(IA). Voltage-dependent K+ current, activated by depolarization. It is
characterized by a hyperpolarized voltage-dependent activation, with current
activation at subthreshold voltages and rapid inactivation during prolonged
depolarizations. In dendrites it is mediated primarily by Kv4.2 subunits.
H-current
(Ih). Slow, non-inactivating nonspecific cationic current that is tonically
active at resting membrane potential and is further activated by
hyperpolarization. It is mediated by HCN1–4 subunits.
T-type Ca2+ current
(ICa,T). Voltage-dependent Ca2+ current that activates at subthreshold
voltages and inactivates rapidly during prolonged depolarization. Upon
repolarization, channels close slowly (slow de-activation). It is mediated by
Cav3.1–3.3 subunits.
Persistent Na+ current
(INaP). A fast voltage-dependent Na+ current that activates at subthreshold
depolarizations but fails to inactivate. The molecular correlate of INaP is
still intensively discussed.
M-current
(IM). A voltage-dependent K+ current that activates at subthreshold
depolarizations but fails to inactivate. In brain neurons it is mediated
primarily by KCNQ1 and KCNQ2 subunits (termed also Kv7.1 and Kv7.2 subunits).
圖四是一些藥理學測試
旨在觀察阻斷某些特殊離子通道後的細胞生理反應
圖五在說明單一細胞如何影響整群細胞的生理活動
妳的問題要先回頭去看圖一
了解不同離子通道的分佈以及其特性
再從圖二的離子通道表現的調節去想這些新增的通道如何改變軸突的生理反應
才能知道各通道對軸突可塑性的效益何在
※ 引述《cathyswallow (小雁子)》之銘言：
: 【問題】：
: 這幾天在看一篇nature的文章
: Plasticity of intrinsic neuronal
: properties in CNS disorders
: 全文可以連結http://go2.tw/n59
: 文章中提到許多離子電流
: ex: h-current , M-current, I Na,p...等
: 尤其fig4 and fig5更是不解
: 【問題起因】：
: 想要了解對於dendritic plasticty的效益為何?
: 【個人看法】：
: A type current: Enhanced AP back-propagation, change in firing mode.
: T-type Ca2+ current: Ehhanced generation of dendritic Ca2+ spikes, change in firing mode.
: H- current: Enhanced EPSP summation
: 那對於dendritic plasticty的效益為何?謝謝
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