Re: [發問] 聖約翰純路跟皮膚外用藥膏？

看板Aromatherapy作者antioxidant (0.0)時間7年前 (2017/02/21 18:56)推噓8(8推 0噓 3→)

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antioxidant

02/21 13:06,

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mandychou

02/21 14:11,

02/21 14:11

A酸應該是以A醇的結構儲存在肝臟才對...=.= 找了2篇文章，一篇是文獻，一篇是書，2篇都各有引用的文獻以下指的都是口服A酸，外用A酸似乎沒有這些困擾.. 1.Ramos-e-Silva M, Hexsel DM, Rutowitsch MS, Zechmeister M. Hydroxy acids and retinoids in cosmetics. Clin Dermatol. 2001 Jul-Aug;19(4):460-6. 463頁 Meals, particularly those with fat content, improve retinoid absorption. Because of its lipid solubility, etretinate has extensive and prolonged storage in fat resulting in a serum half life of 80–160 days. Upon discontinuing the drug, a low level may be detected in the blood for 2 years or more[1]Retinol released from the liver is carried in the circulatory system by plasma retinol-binding proteins. 從肝臟釋放出的A醇在結束口服治療2年或更久時間後，仍有少量能在血液中被檢測到。 2.T. Krieg et al. (eds.), Therapy of Skin Diseases：A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis, 2010 80頁 Women of childbearing potential who have been treated with acitretin must continue using contraception for 3 years in view of its teratogenic effects [2] . 有懷孕可能的女生在中止口服acitretin治療後，最好持續避孕3年 83頁 One major side effect of all retinoids is teratogenicity, especially in early pregnancy which can persist for up to 2 years after cessation of orally administered retinoids such as etretinate which may persist in the body for several years. 所有A酸有致畸性，在口服A酸中止後，A酸留在身體裡的時間可能長達2年，etretinate甚至可能更久。引用文獻： 1. Saurat JH. Systemic retinoids. What's new? Dermatol Clin. 1998 Apr;16(2):331-40. 2. van de Kerkhof PC (2006) Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology. Dermatol Ther 19(5):252–263 -- ※ 發信站: 批踢踢實業坊(ptt.cc), 來自: 110.28.197.234 ※ 文章網址: https://www.ptt.cc/bbs/Aromatherapy/M.1487674594.A.644.html

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Olalalalala

02/21 19:06, , 1^F

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sarah32kimo

02/21 21:41, , 2^F

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sleepmilk

02/21 22:15, , 3^F

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