[申覆] 藥治1 和調劑61
想請問一下大家這樣合不合理
調劑61題
下列藥品，何者與葡萄柚汁併服使用時，不需顧慮交互作用？
(A) felodipine (B) lovastatin (c) cyclosporine (D) diazepam
我在applied 94-6的Table 94-3
上面寫到CYP3A4的 Neonatal Substrate
包括Acetaminophen, alfentanil, carbamazepine,
cisapride, diazepam, erythromycin, lidocaine, midazolam, t
heophylline, verapamil, R-warfarin
在known developmental pattern 提到
上述CYP3A4的 Neonatal Substrate 為Low activity in the first month of life,
with approach toward adult level by 6-12 months of postnatal age.
Pharmacokinetic data for CYP3A4 subtrates suggest that adult activity may
be exceeded between 1 and 4 years of age. Activity then progressively
declines, reaching adult level at the conclusion of puberty.
藥治 第1題
下列藥品中，何者可改善2 歲以下嬰幼兒的鼻炎症狀，且較不會造成中樞神經抑制的
副作用？
(A) hydroxyzine(B) dexchlorpheniramine(c) loratadine(D) cetirizine
Loratadine和 cetirizine都是第二代抗組織胺 且中樞神經副作用接為low to none
而且Applied 25-14的 Table 25-3上面有寫到
Cetirizine 可用在12~23 mo: 2.5mg QD or 2.5 mg Q 12 hr
6~11mo: 2.5mg QD
Infants <6 mo: Safe and effective use has not been established.
Loratadine: Child <2 yr: Safe and effective use has not been established.
此外Cetirizine 在Anticholinergic 方面的副作用為low to none
而Loratadine在Anticholinergic 方面的副作用為 low
所以我認為這題應該選D也可以
不知道大家覺得怎麼樣??
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◆ From: 218.167.189.1
※ 編輯: yeast2 來自: 218.167.189.1 (02/18 00:48)
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