[新聞] AZ抗體療法失敗
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路透社 REUTERS
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Vishwadha Chander
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AstraZeneca says antibody treatment failed in preventing COVID-19 in exposed
patients
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(Reuters) -Anglo-Swedish drugmaker AstraZeneca said on Tuesday a study of its
monoclonal antibody treatment, AZD7442, did not meet the main goal of
preventing symptomatic COVID-19 in people recently exposed to the novel
coronavirus.
The company said the participants in the trial were unvaccinated adults older
than 18 years with confirmed exposure to a person with the coronavirus within
the past eight days.
AZD7442 reduced the risk of developing symptomatic COVID-19 by 33% compared
to a placebo, which was not statistically significant, the company reported.
“While this trial did not meet the primary endpoint against symptomatic
illness, we are encouraged by the protection seen in the PCR negative
participants following treatment with AZD7442,” Mene Pangalos, AstraZeneca
executive vice president, said in a statement.
AstraZeneca is also studying the treatment in a pre-exposed patients trial
and for preventing more severe disease.
The monoclonal antibody therapy belongs to a class of drugs which mimic
natural antibodies the body produces to fight off the infection.
Rivals Regeneron Pharmaceuticals Inc and Eli Lilly & Co have both developed
monoclonal antibody therapies which have been authorised for use in the
United States to treat patients infected with the virus.. The European
Medicines Agency (EMA) has approved Regeneron’s therapy and is reviewing
similar drugs from Eli Lilly, Celltrion and one developed by GlaxoSmithKline
and Vir Biotechnology Inc.
AstraZeneca in October enlisted Swiss contract manufacturer Lonza to produce
the antibody drug in Portsmouth, New Hampshire, starting in the first half of
2021.
AZD7442 is being developed with support from the U.S. government. AstraZeneca
in March announced a deal with the U.S. government to supply up to half a
million doses of AZD7442. The company said on Tuesday it is now in talks with
the U.S. government regarding next steps on the deal.
AZ的抗體療法AZD7442實驗結果不好
AZD7442比安慰劑減少了33%的發病的機率 但沒有達到顯著
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https://reut.rs/3zuRCi7
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※ 編輯: st900278 (157.147.34.142 日本), 06/15/2021 19:02:54
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