[STEM] grow kidneys inside GM mouse
作者: biocommander (世翔) 看板: Medicine
標題: [STEM] grow kidneys inside GM mouse
時間: Wed Apr 14 13:53:10 2010
標題：Professor Hiromitsu Nakauchi finds way to grow kidneys inside GM mouse
March 10, 2009 12:00AM
‧Kidneys grown inside mouse using iPS cells
‧Bladder inflates, urine produced as normal
‧Next step to grow monkey organs in pigs
SCIENTISTS have successfully used implanted cells to create kidneys inside a
mouse whose parents were genetically engineered so their offspring would not
be born with the organs.
The team, headed by Professor Hiromitsu Nakauchi of Tokyo University's
Institute of Medical Science, extracted a fertilised egg obtained through the
normal mating of the genetically modified parents.
The embryo was then implanted with induced pluripotent stem, or iPS, cells
from a mouse with kidneys and then transplanted into the womb of a surrogate
mother.
The baby mouse was born with kidneys and it is believed its bladder inflated
and it produced urine as normal, MCT news agency reported
Implanted iPS cells are thought to have compensated for the kidneys the mouse
should have been born without.
The team now plans to use the research to create internal organs of monkeys
inside pigs.
"If we become able in the future to create human kidneys inside pigs, we'll
be able to solve the problem of a lack of organs for transplant surgery,"
Prof Nakauchi told MCT.
附上網址：http://tinyurl.com/yy9uj9a
Nature 461, 91-94 (3 September 2009) complete mouse from iPS
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