[轉錄][轉錄][轉錄]荒木飛呂彥登上Cell封面 XD
※ [本文轉錄自 Gossiping 看板]
作者: oxylin (羊男的悲傷迷宮)
標題: [轉錄][轉錄]荒木飛呂彥登上Cell封面 XD
時間: Wed Sep 12 17:05:33 2007
※ [本文轉錄自 oxylin 信箱]
作者: GiseleBch (幸福的小手) 看板: GiseleBch
標題: 荒木飛呂彥登上Cell封面 XD
時間: Tue Sep 11 20:58:39 2007
http://www.cell.com/content/current#cover_caption
大圖: http://0rz.tw/5b34p
cover caption
On the cover: Presynaptic plasticity is a fundamental, yet poorly understood,
neural phenomenon that is thought to be the basis of learning and memory.
In this issue, Yao et al. (pp. 943–957) identify a novel ubiquitin ligase
named SCRAPPER, which is responsible for tuning of synaptic vesicle release
probability. SCRAPPER ubiquitinates presynaptic active zone protein RIM1,
triggering its proteasomal degradation. Neurons from the Scrapper-knockout
mice have hyper electrophysiological activity and contained increased amount
of RIM1, and these phenotypes could be rescued by re-expression of SCRAPPER
or knockdown of RIM1. The results highlight the importance of protein
degradation in the regulation of synaptic activity in vivo. On the cover,
the purple SCRAPPER humanoid is putting blue heart-shaped ubiquitins on the
red RIM creatures. Japanese manga artist Hirohiko Araki created the cover
image with scientific direction from Drs. Setou and Ageta.
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誤以為自己是救世主
妄想介入一切
妄想發揮自己的重要性
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