A Cell paper from Taiwan
Cell, Vol 128, 1205-1217, 23 March 2007
A Map of Olfactory Representation in the Drosophila Mushroom Body
Hui-Hao Lin,1,2 Jason Sih-Yu Lai,1,2 An-Lun Chin,1,2 Yung-Chang Chen,3,4 and
Ann-Shyn Chiang1,2,3,5,6,
1 Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013,
Taiwan, ROC
2 Department of Life Science, National Tsing Hua University, Hsinchu 30013,
Taiwan, ROC
3 Brain Research Center, National Tsing Hua University, Hsinchu 30013,
Taiwan, ROC
4 Engineering and System Science group, Department of Electrical Engineering,
National Tsing Hua University, Hsinchu 30013, Taiwan, ROC
5 Department of Life Science, National Central University, Taoyuan 32001,
Taiwan, ROC
6 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY
11724, USA
Corresponding author
Ann-Shyn Chiang
aschiang@life.nthu.edu.tw
Summary
Neural coding for olfactory sensory stimuli has been mapped near completion
in the Drosophila first-order center, but little is known in the higher brain
centers. Here, we report that the antenna lobe (AL) spatial map is
transformed further in the calyx of the mushroom body (MB), an essential
olfactory associated learning center, by stereotypic connections with
projection neurons (PNs). We found that Kenyon cell (KC) dendrites are
segregated into 17 complementary domains according to their neuroblast clonal
origins and birth orders. Aligning the PN axonal map with the KC dendritic
map and ultrastructural observation suggest a positional ordering such that
inputs from the different AL glomeruli have distinct representations in the
MB calyx, and these representations might synapse on functionally distinct
KCs. Our data suggest that olfactory coding at the AL is decoded in the MB
and then transferred via distinct lobes to separate higher brain centers.
http://www.cell.com/content/article/abstract?uid=PIIS0092867407003170
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